The South End has been the traditional neighborhood of Irish-Americans in the city, and became known as "Little Dublin," specifically centered around southern portions of Downtown Dubuque. Remnants of Irish culture still survive in the South End, with Irish pubs such as Murph's South End Tap, the Busted Lift, and stores such as Shamrock Imports still operating in the area. Irish culture in Dubuque also revolves around the city's Irish Catholic churches, namely: St. Columbkille's, St. Patrick's, and St. Raphael's Cathedral.
Today, the South End is much larger, and includes all of the land south of Dodge Street, east of Fremont Avenue (but including areas of west of it), and north of the Key West area. The South End has many of the city's "old money" neighborhoods, especially along South Grandview and Fremont Avenues, and around the Dubuque Golf & Country Club. Many South End neighborhoods have a more spacious and park-like appearance, contrasting with the more urban North End.
Other Important sites in the South End include: